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It works by attaching to IGF-1 receptors on cells, which then activate key internal cell pathways, including PI3K-Akt and MAPK
Using random forest regression as the predictive model, we identified pathways commonly associated with NRF2, such as reactive oxygen species (ROS) and xenobiotic metabolism, in addition to reduced glutathione and NADP levels, as top features associated with NRF2 dependency (Fig
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