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Collectively, this evidence is consistent with the hypothesis that semaglutides primary value in the context of cognitive health may lie in prevention rather than treatment, particularly for cognitive decline driven by vascular and metabolic dysfunctions

Manufacturing standards matter significantly

Future studies should explore whether perioperative hydration protocols, electrolyte monitoring, or cardiovascular screening could help mitigate these risks while maximizing the benefits of GLP-1 agonists in orthopedic surgical populations

Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology