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Reactive oxygen species are produced by electron leak from aerobic respiration by mitochondria
All primer sets were designed from mRNA sequences spanning big introns to avoid amplification from possible genomic DNA contamination
SURMOUNT-MAINTAIN (Horn 2026, 112 weeks): continued top dose -21.9% vs 5 mg step-down -16.6% vs placebo -9.9%, rescue therapy 8/25/67%: Aronne JAMA 2024
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