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While GLP-1 receptors are expressed on immune cells, there is no clear indication that semaglutide triggers new autoimmune conditions or worsens existing disease activity in most patients

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Preclinical studies have demonstrated that triple receptor agonists (RAs) activating all three receptors (GLP-1, GIP, and GCG) produce more pronounced weight loss than dual agonists targeting only two receptors [6]