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All statistical analyses were performed in GraphPad Prism v9.2 (GraphPad Software, La Jolla, CA)

Patients experiencing nausea, vomiting, or diarrheacommon side effects, especially during dose initiation or escalationmay inadvertently decrease their consumption of both food and beverages while experiencing increased fluid losses, resulting in dehydration that manifests as oral dryness

Depending on clinical findings, additional testing may include ambulatory ECG monitoring (Holter monitor or event recorder), echocardiography to assess cardiac structure and function, or exercise stress testing if ischemia is suspected