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It may be an enzyme called NNMT quietly throttling your fat cells' metabolism
Another study conducted by the University of California found that B12 supplements improved energy levels and reduced fatigue in individuals with chronic fatigue syndrome
The result is a vicious cycle where declining NAD+ leads to worse metabolic function, which can lead to weight gain, which increases NNMT activity further
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![Physiologic effects of GLP-1 (adapted from Granata et al. [11])](https://www.researchgate.net/publication/359199250/figure/fig1/AS:11431281081130351@1661532031197/Physiologic-effects-of-GLP-1-adapted-from-Granata-et-al-11.png)
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