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Substitution with conservative amino acids of three residues also ablated activity, whereas the fourth, a phenylalanine, was replaceable by tyrosine without loss of activity

Animal and laboratory studies have suggested that some of these peptides can influence blood vessel formation which from an injury perspective, can indicate healing fibroblast activity, collagen production, reduce inflammation, and improve the healing response in the things that were most interested in from a sports medicine and surgery perspective: tendons, ligaments, muscles, cartilage, and other tissues, Frank said

PubMed Nauck, M.A., Quast, D.R., Wefers, J., & Meier, J.J