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Immunogenicity: No Antibody Formation A critical safety consideration for any peptide therapy is immunogenicity, the potential to trigger immune system responses that could lead to allergic reactions, reduced efficacy through antibody neutralization, or autoimmune complications

Usman et al., 2020), When B16F10 melanoma cells were treated with 050 m SP, it was found that SP to induce melanin synthesis in a dose-dependent manner by increasing the expression of MITF and tyrosinase via increasing CREB phosphorylation ( In vitro , SP at concentrations of 050 mol/L enhanced melanogenesis in vivo and in vitro by increasing melanin content and Tyr and MITF expression (Heriniaina et al., 2018)

In contrast, a small fraction of lymphoma and leukemia cell lines successfully grow in these gels [28, 30], suggesting the presence of TIC or TIC-like cells even in established lymphoma/leukemia cell lines cultured in vitro

None of the four peptides are approved by Health Canada at this time