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Noteworthy, the association of GLP-1RAs and SGLT-2is is representing a new pharmacological opportunity opening an innovative scenario with potential additive pleiotropic effects that will require further studies
The active compound is tirzepatide, a synthetic peptide that acts as a dual agonist at both the glucose-dependent insulinotropic polypeptide receptor (GIPR) and the glucagon-like peptide-1 receptor (GLP-1R)
F.TraversJ
J Neurochem 148(3):426439 Imai H (2010) New strategy of functional analysis of PHGPx knockout mice model using transgenic rescue method and Cre-LoxP system
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