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Active Skin Conditions: Avoid applying copper peptides to areas with active infections, open wounds (unless specifically for wound healing under medical supervision), or severely compromised skin barrier until these conditions resolve
If needed for a clear medical indication (such as treating pellagra in a pregnant patient), niacinamide can be used with caution, but unnecessary high-dose B supplementation is avoided in pregnancy
Apply a spot treatment if desired, but resist the urge to extract
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