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Prolonged overdose of B6 (150-200 mg/day) over weeks can cause severe sensory-nervous-system dysfunction and ataxia.37 With normal usage serious adverse effects are not reported for pyridoxine (vitamin B6), however, diarrhoea, emesis and rosacea-like dermatitis may be observed in some cases (38)
Strong AHAs/BHAs (Glycolic, Salicylic Acid): Using these with kojic acid can lead to excessive exfoliation, leading to irritation, redness, and patchy pigmentation, especially if you have sensitive or dusky skin
Adding a natural ingredient with a high-slip factor means your serum will glide on like a dream, absorb quickly, and leave your skin looking dewy and silky, not oily
