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Some psychiatric medications affect appetite or weight, and early GLP-1 nausea can affect whether you take them consistently
The primary risk is receptor downregulation if gaps exceed 57 days, which may slow pigmentation progression and require an extra 12 weeks to reach plateau
Recommended protocol: Washout: 25 to 30 days Starting dose: 2mg weekly Week 5: escalate to 4mg Week 9: escalate to 8mg Week 13: escalate to 12mg based on response This accelerated schedule saves 4 weeks compared to the standard titration
Medical history of pancreatitis, gallbladder disease, renal impairment, or gastroparesis should be disclosed, as these may influence the suitability of GLP-1 receptor agonists
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