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Duration of diabetes also mattersindividuals with shorter disease duration and preserved beta-cell function generally respond more robustly to GLP-1 receptor agonists than those with longstanding diabetes and significant beta-cell exhaustion
2025 set the tone with high-profile battles like the Metsera bidding war between Pfizer and Novo Nordisk which finally closed, with Pfizer winning, for $10bn [17] , underscoring the strategic value of next-generation assets such as Metseras long-acting injectable asset, MET-097i
Tirzepatide combines GLP-1 receptor agonism with GIP (glucose-dependent insulinotropic polypeptide) receptor activity, which amplifies its effect on blood sugar control and weight reduction
This combined activity distinguishes Retatrutide from single-pathway GLP-1 therapies and dual-agonist medications such as tirzepatide
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