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Orforglipron also showed clinically meaningful improvements from baseline across key cardiovascular risk factors, including non-HDL cholesterol, HDL cholesterol, VLDL cholesterol, total cholesterol, systolic blood pressure and triglycerides
Common medications include semaglutide (Ozempic and Wegovy) and liraglutide (Saxenda)
This alone is enough to generate 15% to 22% total body weight loss
In terms of incoherence, the design-by-treatment interaction model did not identify global inconsistency in the analyses for both primary outcomes (ESM Tables 4 and 5), while local inconsistency was also low
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