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Approval of tirzepatide (brand name Mounjaro/Zepbound), an even more efficacious medication, soon followed in 2023
The resulting pentapeptide demonstrated potency comparable to GHRP-6 in multiple models: EC = 1.3 nmol/L in rat pituitary cells, ED = 80 nmol/kg in anesthetized rats, and ED = 2.3 nmol/kg in conscious swine
Aip regulates cAMP signalling and GH secretion in GH3 cells
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