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Given the results from recent studies, the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) recommend that patients with T2D and clinical cardiovascular disease (CVD) with inadequate glucose control despite treatment with metformin should receive an SGLT2 inhibitor or GLP-1 receptor agonist
Optimal dosing frequency: The peptides short plasma half-life (~0.5-2 hours) suggests frequent administration might sustain tissue concentrations more effectively than single daily dosing, but no formal dose-frequency comparison trials exist
In a dedicated MASLD substudy involving people with obesity and significant liver fat, retatrutide produced effects that many hepatologists considered unprecedented for a drug still in phase 2
The rashes resemble patches of pinpoint red or purple spots, known as petechiae
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