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Clinical and experimental pharmacology & physiology

In the eye, Sosne et al., Exp Eye Res 2001 reported accelerated corneal re-epithelialisation and reduced inflammation after injury, and in the central nervous system Xiong et al., J Neurosurg 2012 found that T4 initiated six hours after experimental traumatic brain injury improved sensorimotor and spatial-learning recovery while enhancing hippocampal neurogenesis

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this is the conservative upper end for most research protocols