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Moiz A, Filion KB, Tsoukas MA, Yu OH, Peters TM, Eisenberg MJ (2025) Mechanisms of GLP-1 Receptor Agonist-Induced Weight Loss: A Review of Central and Peripheral Pathways in Appetite and Energy Regulation
In patients with T2DM, where islet neogenesis and -cell replication are normal, increased apoptosis is the main cause of the decrease in their -cell numbers, so preventing -cell apoptosis may become an effective means of treating T2DM ( GLP-1 has a beneficial effect on -cell function by promoting -cell proliferation and neogenesis and reducing apoptosis (Zheng et al., 2022)
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We do not believe the licensing agreement with Hansoh will preclude Merck from expanding its presence in obesity through further external business development activities, William Blair analyst Andy Hsieh wrote in a Wednesday note to clients
