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After stopping the medication, participants taking semaglutide regained 11.6% of their body weight, and those taking a placebo regained 1.9%, leading to a net weight loss of 5.6% in the semaglutide group and 0.1% in the placebo group

Description Tirzepatide: Complete Research Guide Dual GIP/GLP-1 Receptor Agonist Mechanisms, Clinical Evidence, and Metabolic Research Last updated: March 2026 Executive Summary Tirzepatide is a first-in-class dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist developed by Eli Lilly and Company

2017;86:749-775.[DOI] 49

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