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However, one potential side effect of rapid weight loss with these medications is a condition now commonly referred to as Ozempic face. This term is specifically used to describe the changes in facial appearance experienced by some patients on any course of rapid weight loss, such as hollowed cheeks, a sunken look, and saggy, folding, crinkly skin

The drug remains in active clinical development, with Phase 3 trials currently underway evaluating retatrutide's efficacy and safety across broader populations, including individuals with obesity, type 2 diabetes, and cardiovascular disease

Furthermore, bile acids can induce hepatocyte apoptosis by enhancing the localization of death receptors to the plasma membrane [38]

2 The committee voted the other way on six of them