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Modi A, Khokhar M, Sharma P, Joshi R, Mishra SS, Bharshankar RN, et al
"Triple-Hormone-Receptor Agonist Retatrutide for Obesity A Phase 2 Trial." New England Journal of Medicine , 2023;389:514-526
It peaks 1 to 3 hours after injection, can persist at lower levels for 12 to 24 hours, and typically resolves within 48 hours
The physiological role of native GLP-1 includes stimulating insulin secretion, suppressing glucagon release, and slowing gastric emptyingall mechanisms that contribute to glucose homeostasis
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