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The label also carries a boxed warning for risk of thyroid C-cell tumors, noting that in rodents semaglutide causes dose-dependent and treatment-duration-dependent thyroid C-cell tumors at clinically relevant exposures, and that it is unknown whether Ozempic causes thyroid C-cell tumors, including medullary thyroid carcinoma, in humans

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The number of such original and meta-analytical studies is limited so far, as shown in Table 2 [10, 4047]

At the highest studied dose (12 mg weekly), side effects peaked, but many participants were still able to continue treatment with proper titration and support