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La vida media prolongada de tirzepatide se debe a modificaciones estructurales especficas: la sustitucin de alanina por cido 2-aminoisobutrico que confiere resistencia a la degradacin por DPP-4, y la conjugacin con un cido graso C20 que permite la unin reversible a la albmina srica, reduciendo la degradacin enzimtica

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GLP-1s suppress appetite and alter hunger cues, which means they carry real risks for individuals with certain medical conditions or a history of eating disorders

These results suggest that the decline in glutathione in neurons is more critical for the brain atrophy than that in astrocytes