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Over the last decade, glucagon-like peptide-1 receptor agonists (GLP-1RAs) have become integral in the management of T2D owing to their capacity to improve glycemic control, promote weight loss, and reduce the incidence of major adverse cardiovascular events (MACE)

Use provider follow-ups for dose adjustments and symptom checks rather than pushing the dose alone

The differential posttranslational processing of proglucagon in the pancreas and gut results in the pancreas in the formation of glucagon, the GRPP, a small fragment corresponding to the proglucagon sequence (PG) 6469 and the major proglucagon fragment corresponding to PG 7260 (121) (see Fig

End of combination therapy was defined as the day that treatment with metformin, the exposure drug, or the control drug ceased or when another glucose-lowering drug was initiated