The first is the antioxidant barrier: polyphenols establish antioxidant defense by activating the Nrf2 signaling pathway, and Nrf2 upregulates the expression of HO-1, SOD-1, NQO-1 and other oxidative genes, so as to increase the number of antioxidant enzymes (SOD/CAT/GPX/GSH), and to neutralize cisplatin-induced reactive oxygen species (ROS) and reactive nitrogen species (RNS)
Start with just a tsp of fiber rich food or a pinch of a slow fermenting soluble fiber supplement (PHGG) and gradually increase as tolerated
However, other discussions focus on side effects that are otherwise not well established (e.g., menstrual cycle changes, increased fertility, depression, anxiety, flu vaccine sensitivities, myalgias), which merit further study
Methods Animals Sera were collected from 5 female Swiss albino mice and 5 female albino rats of age 6 weeks