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CJC-1295 with DAC has an approximately 8-day half-life allowing weekly or twice-weekly dosing, while CJC-1295 without DAC has a short half-life requiring frequent dosing matched to each Ipamorelin administration
By providing a common framework, the guidance helps shift the conversation from whether NAMs can be considered to how they can be appropriately applied to answer specific regulatory questions, e.g., derisking treatmentrelated findings observed in animal studies with humanrelevant mechanistic data
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