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To date, no clear clinical evidence has been found to suggest the tumorigenic effect of GLP-1RAs (226), whereas plenty of studies have indicated that GLP-1RAs can inhibit the growth of ovarian, breast, prostate, and pancreatic cancer (227, 228)

However, some women may experience a reduced milk supply or find that they need to supplement breastfeeding with formula

The substrate-binding pockets are sandwiched between COP1 and DET1, and this spatial arrangement suggests only flexible VP motifs can access the binding pockets (Supplementary Fig