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As we did not observe any discontinuation of treatment during the study period, it remains unclear whether pwIIH successfully treated with GLP-1-RAs sustain their weight loss, or a yo-yo effect occurs [44], which would pose an increased risk for a disease relapse
In addition, obesity could inhibit hepatic utilization of BCAAs and cause the inactivation of BCKDH by increasing the ratio of BCKDK (BCKDH kinase)/PPM1K (BCKDH dephosphorylase) in hepatocytes
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Studies in chicken embryos suggest that at least part of the mechanism by which BPC-157 promotes vascular growth is through the stimulation of VEGFR2, a cell surface receptor active in the nitric oxide signaling pathway [4], [7], [8]
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