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According to statistics, there are currently approximately 50 million people living with AD worldwide, and this number is expected to increase to 152 million by 2050 as the population ages, making it a major challenge for global public health (Dissanayaka et al., 2024)

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A1AT appears to inhibit viral infection by targeting two crucial proteases involved in the pathophysiology of the virus: the transmembrane serine protease 2 (TMPRSS2) and the ADAM17 (123, 124)