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However, the larger ACT trial (n=2,308) did not confirm this benefit (ACT Investigators, Circulation, 2011) [68]

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To understand the non-monotone behavior of GSH, it is crucial to consider that there are two incoming fluxes to GSH, GS and GR, and two outgoing fluxes, GPX and a large flux out into the blood [Figure 2B]

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