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GBD 2019 Risk Factors Collaborators

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Glycaemic control and insulin sensitivity in T2D models

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Kidney/liver: No routine dose adjustment is typically required, but monitor closelysevere GI effects can cause dehydration and worsen kidney function

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The goal shifts from introducing new physiological changes to sustaining the beneficial ones already underway, which is why many patients maintain their weight loss trajectory for months at a single dose level

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