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These newer agents enable a more personalized balance between efficacy and safety through strategies such as add-back therapy to mitigate bone mineral density loss and vasomotor symptoms (7, 8)

Behavioral intervention consisted of counseling by a dietitian or similarly qualified healthcare professional every 4 weeks via in-person visits or telephone on adherence to a reduced-calorie diet (500 kcal deficit a day relative to the energy expenditure estimated at randomization) and increased physical activity (150 minutes a week encouraged, for example, walking), both recorded daily (via a diary, app or other tools, which were reviewed during counseling sessions)