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In a 2-year trial involving patients with type 2 diabetes mellitus (T2DM) and high cardiovascular risk, more events of diabetic retinopathy complications occurred in patients treated with semaglutide 0.5 and 1 mg once weekly injections (3%) compared to placebo (1.8%)

In an in vitro model of Erastin-induced ferroptosis in PC12 neuronal cells, the iron inhibitor curcuminpolydopamine nanoparticles (Cur-PDA NPs) markedly enhanced the chelation of Fe 3+ and Fe 2+ , upregulated superoxide dismutase (SOD) and GSH expression, reduced Fe 2+ and ROS levels, inhibited lipid peroxidation, restored mitochondrial function, and attenuated neuronal ferroptosis

Methylcobalamin is often preferred due to its higher bioavailability and direct usability

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