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Nevertheless, studies utilizing more specific biomarkers of vitamin B 12 status, including measures of holo-transcobalamin and methylmalonic acid, have shown more consistent results and a trend towards associations between poor vitamin B 12 status and faster cognitive decline and increased risk of Alzheimers disease (82-86)

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Platelets 34(1):2176173 Gaudry SE, Sitar DS, Smyth DD, McKenzie JK, Aoki FY (1993) Gender and age as factors in the inhibition of renal clearance of amantadine by quinine and quinidine

Note that these doses are specific to cyanocobalamin, the preferred supplemental form of vitamin B12, as there is insufficient evidence to support the efficacy of the other forms, like methylcobalamin