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Conversely, in a recent randomized, double-blind, placebo-controlled study involving twenty healthy volunteers, a once-weekly injection of a GLP-1R agonist, dulaglutide, for three weeks did not influence HPA axis activity, showing no significant effects on circadian rhythms of blood or salivary cortisol secretion, and the level of this hormone also was not changed after the dexamethasone suppression test in comparison with the placebo-receiving group [78]
According to international guidelines, GLP-1RAs are recommended for patients with type 2 diabetes who have established atherosclerotic cardiovascular disease or are considered at high cardiovascular risk
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It may not be advisable to store supplements in the kitchen or bathroom to reduce the risk of heat and moisture affecting them
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