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Therefore, any relationship between GLP-1 therapy and muscle cramps is more likely to be indirect, mediated through secondary metabolic, nutritional, or fluid balance alterations rather than through direct receptor-mediated effects on muscle tissue
The difference is frequency: The new Wegovy HD 7.2 mg dose injects a larger volume
An important limitation that the field as a whole will need to overcome to achieve such analyses will be the development of validated antibodies to not only the GLP-1R but also the CTR and RAMP subunits of the amylin receptor complex
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