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Moreover, IGF-related molecular mechanisms not only play a role in tumor cells but also affect other nontumor cell components in the microenvironment, such as fibroblasts, macrophages and T cells, demonstrating that targeting IGFs alone cannot completely inhibit tumor growth and progression
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Additionally, GLP-1 influences insulin sensitivity and glucose metabolism, reducing the likelihood of excess calories being stored as fat, particularly in the abdominal region
FIGURE 6 Physiological Role of Ketosteroid Isomerase Steroid hormone production is key to regulation of numerous physiological functions
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