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Comparison of the efficacy of glucagon-like peptide-1 receptor agonists in patients with metabolic associated fatty liver disease: updated systematic review and meta-analysis

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Expert Opinion Conclusion CagriSema, Novo Nordisks dual-hormone combination of semaglutide (GLP-1 RA) and cagrilintide (amylin analogue), demonstrated robust efficacy in the REDEFINE 1 and 2 trials, achieving up to 20.4% mean weight loss in people without diabetes and 13.7% in those with T2Doutperforming GLP-1 monotherapy

It is associated with a higher incidence of complications, and these occur earlier