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Hyperglycemic environments are characterized by abnormal mitochondrial dynamics, a tendency for mitochondria to fission rather than to fuse, excessive mitochondrial fission, reduced mitochondrial fusion, and excessive ROS production in different cell types under hyperglycemic conditions, ultimately leading to mitochondrial dysfunction [93, 94]

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for the B medium, we used peptone (10 g), NaCl (5 g), yeast extract (5 g) and K 2 PO 4 (1 g) in 1 l ddH 2 O, pH of 7.5