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MHRA updates guidance for semaglutide prescribers and patients GOV.UK
Indications: Obesity (BMI 30 kg/m) Overweight (BMI 27 kg/m) with weight-related comorbidities Should be used with dietary and physical activity interventions Contraindications: Hypersensitivity to semaglutide or excipients Pregnancy or breastfeeding Personal/family history of medullary thyroid carcinoma Diagnosis of MEN 2 Side Effects: Very common (10%) : Nausea, vomiting, diarrhea, constipation Common (110%) : Headache, dizziness, fatigue, reflux Less common/rare : Gallstones, pancreatitis, renal impairment Reports of suicidal ideation in post-market surveillance Each pen delivers 2.4 mg of semaglutide in 0.5 mL of clear, colorless solution
The FGF19 analog resulted in a substantial reduction in hepatic fat and enzymes in patients with biopsy-confirmed MASH, as shown in a phase 2A study
It also promotes angiogenesis (the formation of new blood vessels) and enhances the activity of fibroblasts, the cells that help heal wounds and repair tissue
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