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In the PIONEER 5 trial, oral semaglutide demonstrated effectiveness in T2DM patients with moderate renal impairment, thereby offering a new treatment option [64]
Good fat sources include half an avocado (15 grams), a tablespoon of olive oil (14 grams), an ounce of almonds (14 grams), and 4 ounces of salmon (12 grams)
Stimulation of GLP-1Rs exhibits antioxidant and antiapoptotic effects, including improvement of mitochondrial function through cAMP/Epac/PI3K/Akt signaling pathway
In contrast, a pooled analysis of clinical trials reporting separate CV events rates in patients with T2D and CKD did not find GLP1-RA to be associated with a reduction in composite CV event rates [76]
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