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Interaction of LPS with TLR4 on the surface of adipocytes and macrophages triggers signaling cascades via the MyD88 or TRIF adaptors, leading to NF-B activation and induction of pro-inflammatory genes encoding IL-1, IL-6, and TNF- (Cani et al., 2007
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It is also authorized for use alongside a reduced-calorie diet and increased physical activity to aid in weight loss and long-term weight management for adults with obesity or those who are overweight with at least one weight-related health condition
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