metformin vs semaglutide for pcos GLP-1s Lead to Greater Weight Loss and A1C Improvement Than in Patients with Wegovy vs. metformin: Differences, similarities

Lipotoxicity is the accumulation of toxic lipid species in non-adipose tissues such as the liver and is involved in insulin resistance, inflammation, and cellular stress that leads to the development of MASLD to T2DM (168, 169)

Inducing ferroptosis, pyroptosis, or necroptosis can potentiate the efficacy of ICIs by increasing tumor antigen presentation and promoting a pro-inflammatory milieu conducive to immune cell infiltration and activation (226, 227)

Relevant hypotheses include that GIPR agonists may desensitize GIP receptor signaling (189), or that GIPR agonists and antagonists improve metabolism through independent mechanisms (187)

Inflammation Reduction GLP-1 agonists reduce systemic inflammation markers such as CRP and IL6 which correlate with better reproductive success