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In a Mayo Clinic study presented at an annual meeting of the Endocrine Society in July 2025, researchers found that, over 18 months, 40 postmenopausal women who combined the GLP-1 drug tirzepatide (used in Mounjaro and Zepbound) with hormone therapy lost an average of 17 percent of their body weight
However, this is quickly changing as tirzepatide continues to gain traction
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"Ozempic face can also result from a disproportionate loss of muscle tissue due to unintentional and poor eating habits among patients taking GLP-1 medication like Ozempic
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