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It is worth noting that the Ume6 protein complex, as a key node of the specific regulatory pathway, can integrate the regulation of genes related to morphogenesis, adhesion, and hypoxia response, through the formation of dynamic complexes with different cofactors, coordinating hyphal growth, cell adhesion, and hypoxia adaptability, thereby shaping the spatial structure of the biofilm and enhancing its drug resistance and pathogenicity

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Figure 2 More recently, a multiple hits theory has been proposed, with the addition of other pathogenic factors in NAFLD development: low-grade chronic inflammation, genetic and epigenetic mutations, and intestinal microbiota

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