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A deficiency can also cause issues such as diarrhea, nausea, vomiting, lack of appetite, weight loss, pale skin, numbness and tingling in your hands and feet, confusion, irritability, depression, and behavior changes
It is used in research to analyze interactions with the NNMT enzyme and related metabolic pathways involved in energy balance and cellular biochemical processes
Additionally, individuals taking medications that may interact with B12, including metformin or proton pump inhibitors, should consult a healthcare provider before starting supplementation
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