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The liver switches from an anti-inflammatory to a pro-inflammatory state with a decrease in anti-inflammatory cytokines (IL-10, transforming growth factor- [TGF-]) and an increase in pro-inflammatory cytokines (IL-1, IL-6, TNF-) [56]
William P
Patients with certain genetic profiles may achieve significant weight loss in 6 months and maintain it with shorter-term therapy, while others may need 18 to 24 months or continuous use for stable outcomes
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