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Collectively, our data strongly suggest that KL1 does not act on bacteria but instead perturbs the intracellular environment to alter hostpathogen interaction
The peptide is classified as amphiphilic, meaning it has both water-attracting and water-repelling regions, a property related to its mixed hydrophilic and hydrophobic amino acid residues
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This fatty acid moiety enables reversible, non-covalent albumin binding in the systemic circulation, dramatically extending plasma half-life relative to both native amylin and earlier pramlintide analogues
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