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In cell or mouse models, blocking ferritinophagy via knockdown of NCOA4 or Atg5, or with the treatment of 3-methyladenine (3-MA), reduces ferritin degradation and iron overload, partially alleviating ferroptosis and ultimately mitigating rifampicin-induced cytotoxicity, liver steatosis and tissue injury
Prast J et al
Rather than replacing ergothioneine, astaxanthin may complement the body's existing antioxidant defenses
Standard household freezers are acceptable if they maintain consistent -20C temperatures without frost-free cycling, which can introduce temperature fluctuations
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