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Research Mechanism (Mechanism of Action) NNMT normally catalyses the transfer of a methyl group from S-adenosylmethionine (SAM) to nicotinamide, producing 1-methylnicotinamide (1-MNA)
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Administered subcutaneously, its injectable form is rapidly absorbed and distributed to metabolically active tissues, where it specifically binds and inhibits NNMT catalytic activity without interfering with other enzymes in the nicotinamide pathway or NAD+ synthesis
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